Phenotypes Associated with This Genotype

Genotype
MGI:4836985

• Allelic Composition: Smn1^tm1.1Dscd/Smn1^tm1.1Dscd
• Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased grip strength ( J:164889 )

decreased vertical activity ( J:164889 )

• at 60 days

decreased locomotor activity ( J:164889 )

• at 60 days

muscle

increased skeletal muscle fiber size ( J:164889 )

• at 60 days, mice exhibit an increase in larger-sized fibers compared with wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
juvenile spinal muscular atrophy		DOID:12376	OMIM:253400	J:164889