Analysis Tools
cardiovascular system
|
• 16 of 22 mice between E16 and E18 exhibit either ventricular septal defect (VSD), overriding aorta, double outlet right ventricle, or a combination of VSD and one of the other two defects unlike wild-type mice
|
craniofacial
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• at E16, the roof of the mouth is wider than in wild-type mice
|
|
• at E13, the number of apoptotic cells is increased 2-fold compared to in wild-type mice likely as a secondary consequence to failure of palate shelf movement
• however, proliferation of cells during palate development is normal
|
cleft palate
(
J:165556
)
|
• in nearly all mice
|
|
• in some mice
|
embryo
| N |
• mice exhibit normal dorsal root ganglia and thymic rudiments indicating normal neural crest migration
• mice do not exhibit neural tube defects
|
hearing/vestibular/ear
|
• mice exhibit cochlear hair cell defects (hair cell number and outer hair cell row 3 orientation) unlike wild-type mice
|
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• most severe in outer hair cell row 3
|
homeostasis/metabolism
nervous system
|
• mice exhibit cochlear hair cell defects (hair cell number and outer hair cell row 3 orientation) unlike wild-type mice
|
|
• most severe in outer hair cell row 3
|
skeleton
digestive/alimentary system
|
• at E13, the number of apoptotic cells is increased 2-fold compared to in wild-type mice likely as a secondary consequence to failure of palate shelf movement
• however, proliferation of cells during palate development is normal
|
cleft palate
(
J:165556
)
|
• in nearly all mice
|
|
• in some mice
|
growth/size/body
|
• at E16, the roof of the mouth is wider than in wild-type mice
|
|
• at E13, the number of apoptotic cells is increased 2-fold compared to in wild-type mice likely as a secondary consequence to failure of palate shelf movement
• however, proliferation of cells during palate development is normal
|
cleft palate
(
J:165556
)
|
• in nearly all mice
|
|
• in some mice
|
