About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4838145
cx15
Allelic
Composition
Fzd2tm1.1Nat/Fzd2tm1.1Nat
Vangl2Lp/Vangl2+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (34 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in all mice, more common in the caudal neural tube
• cochlear hair cell defects (hair cell number and outer hair cell row 3 orientation) are modestly more severe than in Vangl2Lp heterozygotes
• most severe in outer hair cell row 3

hearing/vestibular/ear
• cochlear hair cell defects (hair cell number and outer hair cell row 3 orientation) are modestly more severe than in Vangl2Lp heterozygotes
• most severe in outer hair cell row 3

cardiovascular system
• muscular and/or membranous in mice with neural tube defects

embryo
• in all mice, more common in the caudal neural tube

craniofacial
• in 50% of mice

digestive/alimentary system
• in 50% of mice

growth/size/body
• in 50% of mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/18/2025
MGI 6.24
The Jackson Laboratory