Phenotypes Associated with This Genotype

Genotype
MGI:4839510

• Allelic Composition: Erbb2^{tm8(Erbb2)Mul}/Erbb2⁺; Pten^tm1Hwu/Pten^tm1Hwu; Tg(MMTV-cre)7Mul/0
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:133305 )

• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 2.4 compared with 15.5 months

• 25% of tumors are adenomyoepitheliomas

• 25% of tumors are Erbb2 type neoplasms

• 25% of tumors exhibit squamous metaplasia and retention of myoepithelium

• 25% of tumors are glandular, composed of distinctive large cell population that are a signature phenotype of mammary tumors in these mice

• tumors are similar to HER2 and basal-like subtype of human breast cancer

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:133305 )

• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 2.4 compared with 15.5 months

• 25% of tumors are adenomyoepitheliomas

• 25% of tumors are Erbb2 type neoplasms

• 25% of tumors exhibit squamous metaplasia and retention of myoepithelium

• 25% of tumors are glandular, composed of distinctive large cell population that are a signature phenotype of mammary tumors in these mice

• tumors are similar to HER2 and basal-like subtype of human breast cancer

integument

increased mammary gland tumor incidence ( J:133305 )

• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 2.4 compared with 15.5 months

• 25% of tumors are adenomyoepitheliomas

• 25% of tumors are Erbb2 type neoplasms

• 25% of tumors exhibit squamous metaplasia and retention of myoepithelium

• 25% of tumors are glandular, composed of distinctive large cell population that are a signature phenotype of mammary tumors in these mice

• tumors are similar to HER2 and basal-like subtype of human breast cancer

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:133305