Phenotypes Associated with This Genotype

Genotype
MGI:4839563

• Allelic Composition: Tg(Amhr2-SV40TAg)1Dcco/0
• Genetic Background: (C57BL/6 x C3H)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased ovary tumor incidence ( J:82550 )

♀ • 50% of founder females develop ovarian tumors by 6-13 weeks of age

♀ • ovaries are nearly completely substituted by poorly differentiated neoplastic cells with hyperchromatic nuclei and polygonal to oval eosinophilic cytoplasm

♀ • tumor invades the omentum, the mesentery, and the parietal and visceral serosa

increased ovarian carcinoma incidence ( J:82550 )

♀ • ovary tumors are poorly differentiated carcinomas with i.p. metastatic dissemination

increased testis tumor incidence ( J:82550 )

♂ • testicular tumors are seen in 7 of 25 male founders

♂ • testicular tumors are poorly differentiated Sertoli cell tumors

reproductive system

increased ovary tumor incidence ( J:82550 )

♀ • 50% of founder females develop ovarian tumors by 6-13 weeks of age

♀ • ovaries are nearly completely substituted by poorly differentiated neoplastic cells with hyperchromatic nuclei and polygonal to oval eosinophilic cytoplasm

♀ • tumor invades the omentum, the mesentery, and the parietal and visceral serosa

increased ovarian carcinoma incidence ( J:82550 )

♀ • ovary tumors are poorly differentiated carcinomas with i.p. metastatic dissemination

increased testis tumor incidence ( J:82550 )

♂ • testicular tumors are seen in 7 of 25 male founders

♂ • testicular tumors are poorly differentiated Sertoli cell tumors

female infertility ( J:82550 )

♀ • female founders are infertile, probably due to early development of ovarian tumors

renal/urinary system

kidney cyst ( J:82550 )

♀ • two female founders were found to have cystic kidneys

homeostasis/metabolism

hemorrhagic ascites ( J:82550 )

• often bloody ascites are present in the abdominal cavity of founders with tumors

endocrine/exocrine glands

increased ovary tumor incidence ( J:82550 )

♀ • 50% of founder females develop ovarian tumors by 6-13 weeks of age

♀ • ovaries are nearly completely substituted by poorly differentiated neoplastic cells with hyperchromatic nuclei and polygonal to oval eosinophilic cytoplasm

♀ • tumor invades the omentum, the mesentery, and the parietal and visceral serosa

increased ovarian carcinoma incidence ( J:82550 )

♀ • ovary tumors are poorly differentiated carcinomas with i.p. metastatic dissemination

increased testis tumor incidence ( J:82550 )

♂ • testicular tumors are seen in 7 of 25 male founders

♂ • testicular tumors are poorly differentiated Sertoli cell tumors

growth/size/body

kidney cyst ( J:82550 )

♀ • two female founders were found to have cystic kidneys

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ovarian cancer		DOID:2394	OMIM:167000 OMIM:607893	J:82550