Phenotypes Associated with This Genotype

Genotype
MGI:4839756

hm1

• Allelic Composition: Emg1^tm1Hdin/Emg1^tm1Hdin
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:165972 )

• no mice are recovered after E3.5

embryo

abnormal preimplantation embryo development ( J:165972 )

embryonic growth arrest ( J:165972 )

• pre-implantation

absent blastocoele ( J:165972 )

absent inner cell mass ( J:165972 )

• mice fail to form Oct3/4+ or Nanog+ inner cell mass unlike wild-type mice

cellular

abnormal nucleolus morphology ( J:165972 )

• at E3.5, the nucleoli of embryos are large ring shapes unlike in wild-type mice