Phenotypes Associated with This Genotype

Genotype
MGI:4839911

hm2

• Allelic Composition: Il1b^tm1Lvp/Il1b^tm1Lvp
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:136368 )

• following infection with Sterne 34F2 strain of Bacillus anthracis

decreased susceptibility to Togaviridae infection induced morbidity/mortality ( J:52841 )

• following Sindbis virus infection, 4% of mice die compared with 88% of similarly treated wild-type mice

decreased susceptibility to induced morbidity/mortality ( J:59893 , J:82394 )

• only 3 of 16 mice injected with B16M cells die after 12 days compared to all similarly treated wild-type mice (J:59893)

• following injection of B16 melanoma cells (J:82394)

immune system

abnormal macrophage physiology ( J:136368 )

• macrophages exhibit impaired ability to kill Bacillus anthracis compared with wild-type cells

decreased interleukin-1 beta secretion ( J:136368 )

• following exposure of macrophages to LPS or Bacillus anthracis spores

decreased tumor necrosis factor secretion ( J:82394 )

• from macrophages co-cultured with B16 cells

increased susceptibility to bacterial infection induced morbidity/mortality ( J:136368 )

• following infection with Sterne 34F2 strain of Bacillus anthracis

decreased susceptibility to viral infection ( J:135243 )

• neuroadapted Sindbis virus-infected mice exhibit attenuated hind limb paralysis and spinal cord motor neuron degeneration compared with similarly treated wild-type mice

decreased susceptibility to Togaviridae infection ( J:52841 )

• mice infected with Sindbis virus exhibit altered viral spread and reduced severe paralysis and death compared with similarly treated wild-type mice

• however, apoptosis and lesions in the brain following infection are the same as in wild-type mice

decreased susceptibility to Togaviridae infection induced morbidity/mortality ( J:52841 )

• following Sindbis virus infection, 4% of mice die compared with 88% of similarly treated wild-type mice

neoplasm

abnormal tumor vascularization ( J:82394 )

• angiogenesis in mice injected with B16 melanoma cells is nearly absent compared to in similarly treated wild-type mice

decreased metastatic potential ( J:59893 , J:82394 )

• mice injected with B16 cells exhibit reduced metastasis (by volume and density) in the liver compared with similarly treated wild-type mice (J:59893)

• mice injected with B16 cells exhibit decreased metastasis volume, an indicator of metastatic growth, compared with similarly treated wild-type mice (J:59893)

• following injection of B16 melanoma cells, no metastatic tumors are observed unlike in similarly treated wild-type mice (J:82394)

• mice injected with mammary cancer tumor DA/3 exhibit slower and smaller tumor development compared with similarly treated wild-type mice (J:82394)

decreased tumor growth/size ( J:59893 , J:82394 )

• mice injected with B16 cells exhibit decreased metastasis volume, an indicator of metastatic growth, compared with similarly treated wild-type mice (J:59893)

• mice injected with mammary cancer tumor DA/3 exhibit slower and smaller tumor development compared with similarly treated wild-type mice (J:82394)

cardiovascular system

abnormal tumor vascularization ( J:82394 )

• angiogenesis in mice injected with B16 melanoma cells is nearly absent compared to in similarly treated wild-type mice

homeostasis/metabolism

decreased susceptibility to injury ( J:128238 )

• following arterial ligation, mice exhibit reduced and smaller cerebral aneurysm with reduced ssDNA and TUNEL+ cells in the vascular walls compared with similarly treated wild-type mice

hematopoietic system

abnormal macrophage physiology ( J:136368 )

• macrophages exhibit impaired ability to kill Bacillus anthracis compared with wild-type cells