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Phenotypes Associated with This Genotype
Genotype
MGI:4839923
hm4
Allelic
Composition		 Il1btm1Lvp/Il1btm1Lvp
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * C57BL/10 * RIIIS
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1btm1Lvp mutation (0 available); any Il1b mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal blood-brain barrier function ( J:105009 )
• following corticectomy injury, mice exhibit delayed re-establishment of the blood-brain barrier compared with similarly treated wild-type mice

homeostasis/metabolism
decreased susceptibility to injury ( J:105009 )
• following corticectomy injury, mice exhibit reduced GFAP immunoreactivity and delayed re-establishment of the blood-brain barrier compared with similarly treated wild-type mice until day 5

cardiovascular system
abnormal blood-brain barrier function ( J:105009 )
• following corticectomy injury, mice exhibit delayed re-establishment of the blood-brain barrier compared with similarly treated wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory