Analysis Tools
mortality/aging
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• 80% die between 10-12 weeks of age and by 16 weeks of age, 95% die
(J:63300)
• 95% of mice die by 16 weeks of age with multicentric T-cell lymphomas
(J:96010)
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neoplasm
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• 95% of mice die by 16 weeks of age with multicentric T-cell lymphomas
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• thymus, spleen, and lymph nodes show massive infiltration by a monotonous lymphoblastic cell population
• mutants develop aggressive multicentric T-cell lymphomas showing features of lymphoblastic lymphoma with high penetrance by 7 weeks of age
• tumors sustain characteristics of immature thymocytes, including expression of CD25, pTalpha, and activated NF-kappaB
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• tumor cell infiltration is seen in the liver, lungs, kidney, bone marrow and peripheral blood, indicating leukemic phase of the disease
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behavior/neurological
immune system
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• hyperplastic thymus is seen in some mutants at 5-6 weeks of age
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• in 3 week old mutants, particularly the late double negative cells
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• 95% of mice die by 16 weeks of age with multicentric T-cell lymphomas
|
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• thymus, spleen, and lymph nodes show massive infiltration by a monotonous lymphoblastic cell population
• mutants develop aggressive multicentric T-cell lymphomas showing features of lymphoblastic lymphoma with high penetrance by 7 weeks of age
• tumors sustain characteristics of immature thymocytes, including expression of CD25, pTalpha, and activated NF-kappaB
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• 5- to 6-fold increase in size and weight of spleen at 5-6 weeks of age
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• disruption of thymocyte differentiation; all thymocyte subsets express high levels of CD25 and are broadly distributed in the cortex and medulla of the thymus, indicating a failure to downregulate CD25 expression the occurs normally in double positive and single positive subsets after 17-18 dpc
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• 5- to 6-fold increase in size and weight of peripheral (axillary, cervical, and abdominal) lymph nodes at 5-6 weeks of age
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hematopoietic system
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• hyperplastic thymus is seen in some mutants at 5-6 weeks of age
|
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• in 3 week old mutants, particularly the late double negative cells
|
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• 95% of mice die by 16 weeks of age with multicentric T-cell lymphomas
|
|
• thymus, spleen, and lymph nodes show massive infiltration by a monotonous lymphoblastic cell population
• mutants develop aggressive multicentric T-cell lymphomas showing features of lymphoblastic lymphoma with high penetrance by 7 weeks of age
• tumors sustain characteristics of immature thymocytes, including expression of CD25, pTalpha, and activated NF-kappaB
|
|
• 5- to 6-fold increase in size and weight of spleen at 5-6 weeks of age
|
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• disruption of thymocyte differentiation; all thymocyte subsets express high levels of CD25 and are broadly distributed in the cortex and medulla of the thymus, indicating a failure to downregulate CD25 expression the occurs normally in double positive and single positive subsets after 17-18 dpc
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endocrine/exocrine glands
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• hyperplastic thymus is seen in some mutants at 5-6 weeks of age
|
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• in 3 week old mutants, particularly the late double negative cells
|
|
• 95% of mice die by 16 weeks of age with multicentric T-cell lymphomas
|
|
• thymus, spleen, and lymph nodes show massive infiltration by a monotonous lymphoblastic cell population
• mutants develop aggressive multicentric T-cell lymphomas showing features of lymphoblastic lymphoma with high penetrance by 7 weeks of age
• tumors sustain characteristics of immature thymocytes, including expression of CD25, pTalpha, and activated NF-kappaB
|
growth/size/body
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• 5- to 6-fold increase in size and weight of spleen at 5-6 weeks of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| acute lymphoblastic leukemia | DOID:9952 |
OMIM:247640 OMIM:613065 |
J:63300 | |
