Phenotypes for Pten Tg(ARR2/Pbsn-FGF8)3Prb Tg(Pbsn-cre)4Prb MGI:4843916 MGI Mouse

endocrine/exocrine glands

enlarged prostate gland ( J:106650 )

• enlarged prostate gland due to epithelial hyperplasia

• prostatic adenocarcinomas are seen from 9 months onward

• adenocarcinomas are seen in all lobes, although more often in the dorsolateral and ventral lobes than anterior lobes

• 6 of 17 mutants at 9-16.2 months of age and 9 of 10 mutants at 18.2-19.1 months exhibit adenocarcinomas

• adenocarcinomas show loss of heterozygosity of Pten

• 2 of 31 mutants develop a rare form of mucinous adenocarcinoma

• males by 6.5 months of age exhibit hyperplasia and focal-low grade PIN lesions in the prostate

• males older than 7.5 months of age exhibit high-grade PINs

reproductive system

enlarged prostate gland ( J:106650 )

• enlarged prostate gland due to epithelial hyperplasia

• prostatic adenocarcinomas are seen from 9 months onward

• adenocarcinomas are seen in all lobes, although more often in the dorsolateral and ventral lobes than anterior lobes

• 6 of 17 mutants at 9-16.2 months of age and 9 of 10 mutants at 18.2-19.1 months exhibit adenocarcinomas

• adenocarcinomas show loss of heterozygosity of Pten

• 2 of 31 mutants develop a rare form of mucinous adenocarcinoma

• males by 6.5 months of age exhibit hyperplasia and focal-low grade PIN lesions in the prostate

• males older than 7.5 months of age exhibit high-grade PINs

neoplasm

• prostatic adenocarcinomas are seen from 9 months onward

• adenocarcinomas are seen in all lobes, although more often in the dorsolateral and ventral lobes than anterior lobes

• 6 of 17 mutants at 9-16.2 months of age and 9 of 10 mutants at 18.2-19.1 months exhibit adenocarcinomas

• adenocarcinomas show loss of heterozygosity of Pten

• 2 of 31 mutants develop a rare form of mucinous adenocarcinoma

• males by 6.5 months of age exhibit hyperplasia and focal-low grade PIN lesions in the prostate

• males older than 7.5 months of age exhibit high-grade PINs

increased metastatic potential ( J:106650 )

• metastasis of adenocarcionma into lymph nodes is observed, with 50-60% penetrance

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:106650

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 08/02/2024 MGI 6.24