Phenotypes for Pten Tg(ARR2/Pbsn-FGF8)3Prb Tg(Pbsn-cre)4Prb MGI:4843916 MGI Mouse

endocrine/exocrine glands

enlarged prostate gland ( J:106650 )

• enlarged prostate gland due to epithelial hyperplasia

• prostatic adenocarcinomas are seen from 9 months onward

• adenocarcinomas are seen in all lobes, although more often in the dorsolateral and ventral lobes than anterior lobes

• 6 of 17 mutants at 9-16.2 months of age and 9 of 10 mutants at 18.2-19.1 months exhibit adenocarcinomas

• adenocarcinomas show loss of heterozygosity of Pten

• 2 of 31 mutants develop a rare form of mucinous adenocarcinoma

• males by 6.5 months of age exhibit hyperplasia and focal-low grade PIN lesions in the prostate

• males older than 7.5 months of age exhibit high-grade PINs

reproductive system

enlarged prostate gland ( J:106650 )

• enlarged prostate gland due to epithelial hyperplasia

• prostatic adenocarcinomas are seen from 9 months onward

• adenocarcinomas are seen in all lobes, although more often in the dorsolateral and ventral lobes than anterior lobes

• 6 of 17 mutants at 9-16.2 months of age and 9 of 10 mutants at 18.2-19.1 months exhibit adenocarcinomas

• adenocarcinomas show loss of heterozygosity of Pten

• 2 of 31 mutants develop a rare form of mucinous adenocarcinoma

• males by 6.5 months of age exhibit hyperplasia and focal-low grade PIN lesions in the prostate

• males older than 7.5 months of age exhibit high-grade PINs

neoplasm

• prostatic adenocarcinomas are seen from 9 months onward

• adenocarcinomas are seen in all lobes, although more often in the dorsolateral and ventral lobes than anterior lobes

• 6 of 17 mutants at 9-16.2 months of age and 9 of 10 mutants at 18.2-19.1 months exhibit adenocarcinomas

• adenocarcinomas show loss of heterozygosity of Pten

• 2 of 31 mutants develop a rare form of mucinous adenocarcinoma

• males by 6.5 months of age exhibit hyperplasia and focal-low grade PIN lesions in the prostate

• males older than 7.5 months of age exhibit high-grade PINs

increased metastatic potential ( J:106650 )

• metastasis of adenocarcionma into lymph nodes is observed, with 50-60% penetrance

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:106650

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

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