Phenotypes Associated with This Genotype

Genotype
MGI:4843923

cn24

• Allelic Composition: Smo^tm2Amc/Smo^tm2.1Amc; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal artery morphology ( J:135134 )

• at E10.5 and E18.5, mice exhibit arch-artery defects compared with wild-type mice

pulmonary artery hypoplasia ( J:135134 )

• in 4 of 23 mice

abnormal cardiac outflow tract development ( J:135134 )

• mice exhibit partial septation of the outflow tract unlike wild-type mice

persistent truncus arteriosus ( J:135134 )

• in 17 of 23 mice

transposition of great arteries ( J:135134 )

• 2 of 23 mice exhibit complete separation of a transposed aorta and hypoplastic pulmonary artery unlike in wild-type mice

embryo

abnormal neural crest cell apoptosis ( J:135134 )

• mice exhibit cell death in neural crest cells unlike in wild-type mice

cellular

abnormal neural crest cell apoptosis ( J:135134 )

• mice exhibit cell death in neural crest cells unlike in wild-type mice