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Phenotypes Associated with This Genotype
Genotype
MGI:4843924
cn7
Allelic
Composition		 Smotm2Amc/Smotm2.1Amc
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (1026 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (27 available)
Smotm2.1Amc mutation (0 available); any Smo mutation (39 available)
Smotm2Amc mutation (1 available); any Smo mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
decreased cardiac neural crest cell number ( J:135134 )
• the number of cardiac neural crest cells reaching the outflow tract is moderately reduced compared to in wild-type mice
impaired cardiac neural crest cell differentiation ( J:135134 )
• mice exhibit abnormal patterning of cardiac neural crest cells compared to in wild-type mice

cardiovascular system
decreased cardiac neural crest cell number ( J:135134 )
• the number of cardiac neural crest cells reaching the outflow tract is moderately reduced compared to in wild-type mice
impaired cardiac neural crest cell differentiation ( J:135134 )
• mice exhibit abnormal patterning of cardiac neural crest cells compared to in wild-type mice

nervous system
decreased cardiac neural crest cell number ( J:135134 )
• the number of cardiac neural crest cells reaching the outflow tract is moderately reduced compared to in wild-type mice
impaired cardiac neural crest cell differentiation ( J:135134 )
• mice exhibit abnormal patterning of cardiac neural crest cells compared to in wild-type mice

cellular
impaired cardiac neural crest cell differentiation ( J:135134 )
• mice exhibit abnormal patterning of cardiac neural crest cells compared to in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory