Phenotypes Associated with This Genotype

Genotype
MGI:4844193

• Allelic Composition: Kras^tm1Bbd/Kras⁺; Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:161780 )

• the mean lifespan of mice treated tamoxifen is 34-42 weeks

neoplasm

increased adenoma incidence ( J:161780 )

• in mice treated with tamoxifen at weaning

increased lung non-small cell carcinoma incidence ( J:161780 )

• in mice treated with tamoxifen at weaning

respiratory system

increased lung non-small cell carcinoma incidence ( J:161780 )

• in mice treated with tamoxifen at weaning

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:161780