Phenotypes Associated with This Genotype

Genotype
MGI:4849842

• Allelic Composition: Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo/Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

astrocytosis ( J:104655 )

decreased motor neuron number ( J:104655 )

motor neuron degeneration ( J:104655 )

• by 7 to 9 months, mice develop motor neuron disease that progresses rapidly unlike wild-type mice

behavior/neurological

abnormal gait ( J:104655 )

hindlimb paralysis ( J:104655 )

• within 1 to 3 weeks of visible gait disturbance

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
amyotrophic lateral sclerosis type 1		DOID:0060193	OMIM:105400	J:104655