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Phenotypes Associated with This Genotype
Genotype
MGI:4849847
Allelic
Composition
Myo3atm1.1Mckg/Myo3atm1.1Mckg
Genetic
Background
C57BL/6-Myo3atm1.1Mckg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo3atm1.1Mckg mutation (1 available); any Myo3a mutation (110 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
N
• mice exhibit normal vestibular function
• severe at 10 months
• degeneration in the mid-cochlear turn is more severe
• at 2.5 months, mice exhibit significant hearing loss which progreses with age compared with wild-type mice

nervous system
• severe at 10 months
• degeneration in the mid-cochlear turn is more severe

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive nonsyndromic deafness 30 DOID:0110489 OMIM:607101
J:166812


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory