Phenotypes Associated with This Genotype

Genotype
MGI:4849989

• Allelic Composition: Tg(KRT14-HPV16)wt1Dh/0
• Genetic Background: either: FVB.Cg-Tg(KRT14-HPV16)wt1Dh or (involves: C57BL/6 * DBA/2 * FVB/N)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased skin squamous cell carcinoma incidence ( J:20130 )

• by 8 to 12 months, 21% of mice develop well differentiated and moderate to poorly differentiated squamous cell carcinomas

• malignant progression is accompanied by cell junction and extracellular matrix remodeling but is not defined by increased cell proliferation

increased spindle cell carcinoma incidence ( J:20130 )

• in 6 of 169 mice over the last 2 years

integument

abnormal skin morphology ( J:20130 )

• mice exhibit skin dysplasia compared with wild-type mice

skin hyperplasia ( J:20130 )

increased skin squamous cell carcinoma incidence ( J:20130 )

• by 8 to 12 months, 21% of mice develop well differentiated and moderate to poorly differentiated squamous cell carcinomas

• malignant progression is accompanied by cell junction and extracellular matrix remodeling but is not defined by increased cell proliferation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
skin squamous cell carcinoma		DOID:3151		J:20130