Phenotypes Associated with This Genotype

Genotype
MGI:4850030

• Allelic Composition: Tg(Lck-TNFSF13)3919Mhah/0
• Genetic Background: B6.Cg-Tg(Lck-TNFSF13)3919Mhah

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell apoptosis ( J:94628 )

• survival of cultured B-1 B cells is increased 3-fold compared with wild-type cells

• survival of cultured B-1 B cells treated with death agonists (VP-16, doxorubicin, and staurosporin) is increased compared with similarly treated wild-type cells

increased B cell number ( J:94628 )

• in the mesenteric lymph node

increased B-1 B cell number ( J:94628 )

increased CD4-positive, alpha-beta T cell number ( J:94628 )

• in the mesenteric lymph node

increased CD8-positive, alpha-beta T cell number ( J:94628 )

• in the mesenteric lymph node

increased IgA level ( J:94628 )

abnormal immune system organ morphology ( J:94628 )

• in 40% of mice at 9 to 12 months

abnormal spleen morphology ( J:94628 )

• older mice exhibit highly disorganized spleen architecture compared with wild-type mice

spleen hyperplasia ( J:94628 )

• in older mice with incidence increasing with age

intermingled spleen red and white pulp ( J:94628 )

• in older mice

enlarged Peyer's patches ( J:94628 )

• due to increased cell number that increases in incidence and severity over time

abnormal mesenteric lymph node morphology ( J:94628 )

• the percentage of B220+ cells increase slightly while the percentage of CD8+ T cells is slightly decreased in the mesenteric lymph node compared to in wild-type mice

• enlarged blast-like B and T cells accumulate in the mesenteric lymph nodes unlike in wild-type mice

enlarged mesenteric lymph nodes ( J:94628 )

• due to increased cell number that increases in incidence and severity over time

neoplasm

increased chronic lymphocytic leukemia incidence ( J:94628 )

• at 9 to 12 months, mice exhibit lymphoid tumors due to expansion of peritoneal B-1 B cell populations with infiltration into nonlymphoid tissues (lungs and kidneys)

hematopoietic system

decreased B cell apoptosis ( J:94628 )

• survival of cultured B-1 B cells is increased 3-fold compared with wild-type cells

• survival of cultured B-1 B cells treated with death agonists (VP-16, doxorubicin, and staurosporin) is increased compared with similarly treated wild-type cells

increased B cell number ( J:94628 )

• in the mesenteric lymph node

increased B-1 B cell number ( J:94628 )

increased CD4-positive, alpha-beta T cell number ( J:94628 )

• in the mesenteric lymph node

increased CD8-positive, alpha-beta T cell number ( J:94628 )

• in the mesenteric lymph node

abnormal spleen morphology ( J:94628 )

• older mice exhibit highly disorganized spleen architecture compared with wild-type mice

spleen hyperplasia ( J:94628 )

• in older mice with incidence increasing with age

intermingled spleen red and white pulp ( J:94628 )

• in older mice

increased IgA level ( J:94628 )

cellular

decreased B cell apoptosis ( J:94628 )

• survival of cultured B-1 B cells is increased 3-fold compared with wild-type cells

• survival of cultured B-1 B cells treated with death agonists (VP-16, doxorubicin, and staurosporin) is increased compared with similarly treated wild-type cells

growth/size/body

spleen hyperplasia ( J:94628 )

• in older mice with incidence increasing with age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:94628