Phenotypes Associated with This Genotype

Genotype
MGI:4850046

• Allelic Composition: Fbn2^tm1Rmz/Fbn2^tm1Rmz
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Experimental osteolysis occurs more extensively in Fbn1^tm3Rmz/Fbn1^tm3Rmz mice

skeleton

decreased bone mass ( J:166786 )

• mutants exhibit 27% less bone mass by 3 months of age

abnormal skeleton development ( J:166786 )

• mutants exhibit a 55% reduction in bone formation rate by 3 months of age

abnormal bone remodeling ( J:166786 )

• mutants show greater than normal osteolytic response to locally implanted lipopolysaccharide-coated titanium particles

• isolated mutant preosteoclasts cultured with mutant osteoblasts exhibit augmented differentation and activity, indicating greater osteoclastogenic potential of osteoblasts

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
distal arthrogryposis		DOID:0050646	OMIM:PS108120	J:166786