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Phenotypes Associated with This Genotype
Genotype
MGI:4867492
cn6
Allelic
Composition		 Kmt2btm1Afst/Kmt2btm1.1Afst
Amhr2tm3(cre)Bhr/Amhr2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (29 available)
Kmt2btm1.1Afst mutation (0 available); any Kmt2b mutation (65 available)
Kmt2btm1Afst mutation (0 available); any Kmt2b mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal ovarian follicle number ( J:166778 )
• decreased number of primordial, primary, secondary and preantral follicles at 36 weeks old
increased atretic ovarian follicle number ( J:166778 )
• increased number of atretic follicles at 36 weeks of age
reduced female fertility ( J:166778 )
• a small reduction in fertility

cellular
abnormal DNA methylation ( J:166778 )
• 50% decrease in global tri-methylated H3K4 levels in granulosa cells

homeostasis/metabolism
increased circulating follicle stimulating hormone level ( J:166778 )
• increased serum FSH levels at 8 weeks old

endocrine/exocrine glands
abnormal ovarian follicle number ( J:166778 )
• decreased number of primordial, primary, secondary and preantral follicles at 36 weeks old
increased atretic ovarian follicle number ( J:166778 )
• increased number of atretic follicles at 36 weeks of age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory