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Phenotypes Associated with This Genotype
Genotype
MGI:4867495
cn7
Allelic
Composition		 Kmt2btm1Afst/Kmt2btm1.1Afst
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (1006 available)
Kmt2btm1.1Afst mutation (0 available); any Kmt2b mutation (65 available)
Kmt2btm1Afst mutation (0 available); any Kmt2b mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
female infertility ( J:166778 )
• tamoxifen treatment provokes infertility in females regardless of genotype
• after treatment is discontinued, control animals fully recover fertility, whereas mutant females remain infertile

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory