Phenotypes Associated with This Genotype

Genotype
MGI:4867496

hm4

• Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:61314 )

• following traumatic brain injury, more mice die than similarly treated wild-type mice

immune system

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:115225 )

• following treatment with MOG, mice exhibit delayed onset, decreased severity of disease, and reduced demyelination but increased number of inflammatory foci compared with similarly treated wild-type mice

decreased susceptibility to parasitic infection ( J:37696 )

• mice treated with Plasmodium berghei ANKA (PbA)-infected erythrocytes fail to develop cerebral malaria or vascular leakiness unlike similarly treated wild-type mice

• however, mice treated with PbA-infected with erythrocytes exhibit weight loss, anemia, high parasitemia, and die between 15 and 20 days post-infection

homeostasis/metabolism

increased susceptibility to injury ( J:61314 )

• following traumatic brain injury, more mice die than similarly treated wild-type mice

• however, traumatic brain injury-induced blood brain barrier disfunction and accumulation of polymononuclear leukocytes is normal