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Phenotypes Associated with This Genotype
Genotype
MGI:4867498
hm1
Allelic
Composition
Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic
Background
B6.129-Lta/Tnftm1Eug
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta/Tnftm1Eug mutation (0 available); any Lta mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most S. aureus-infected mice die unlike similarly treated wild-type mice

immune system
• in S.aureus-infected mice
• in S.aureus-infected mice
• in S.aureus-infected mice
• in S.aureus-infected mice
• in S.aureus-infected mice
• 28 days after S. aureus infection
• from spleen cells of S. aureus-infected mice
• S. aureus-infected mice exhibit decreased septic arthritis compared with similarly treated wild-type mice
• Staphylococcus aureus-infected mice exhibit greater weight loss, increased mortality, reduced bacterial clearance, decreased IFN-gamma production, decreased septic arthritis, increased IgM serum levels, and decreased antigen-specific IgG serum levels compared with similarly treated wild-type mice
• most S. aureus-infected mice die unlike similarly treated wild-type mice

skeleton
• S. aureus-infected mice exhibit decreased septic arthritis compared with similarly treated wild-type mice

homeostasis/metabolism
• 28 days after S. aureus infection

behavior/neurological
• mice exhibit reduced rapid eye movement (REM) sleep episode frequency compared with wild-type mice
• mice exhibit higher absolute electroencephalogram (EEG) power density non-REM sleep within the slow-wave range compared with wild-type mice
• after sleep deprivation, mice exhibit a greater increase in fast 'slow waves' compared with wild-type mice
• however, a decrease in non-REM sleep episode frequency is compensated by extension of non-REM sleep episode duration

hematopoietic system
• in S.aureus-infected mice
• in S.aureus-infected mice
• in S.aureus-infected mice
• in S.aureus-infected mice
• in S.aureus-infected mice

cellular
• in S.aureus-infected mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory