respiratory system
• apoptosis in the lungs is elevated
|
• lung elastic recoil pressure is reduced
• elastic modulus (stiffness) of lung tissue is decreased
|
• at all lung volumes, lungs have greater compliance than non-transgenic mice
|
cardiovascular system
• mutant elastin is not incorporated into the elastic fibers of the aorta
|
integument
• mutant elastin is not incorporated into the elastic fibers of the skin
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
cutis laxa | DOID:3144 |
OMIM:PS123700 |
J:166809 |