Phenotypes Associated with This Genotype

Genotype
MGI:4867520

• Allelic Composition: Clock^m1Jt/Clock^m1Jt
• Genetic Background: involves: BALB/cJ * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal medium spiny neuron morphology ( J:166742 )

• nucleus accumbens medium spiny neurons have longer and more complex dendrites and exhibit reduced GluR1 expression than those of wild-type mice

• lithium treatment reverses the changes in dendritic morphology

abnormal nucleus accumbens morphology ( J:166742 )

• nucleus accumbens medium spiny neurons have longer and more complex dendrites and exhibit reduced GluR1 expression than those of wild-type mice

abnormal nervous system electrophysiology ( J:166742 )

• phase coupling between nucleus accumbens low-gamma oscillatory activity and delta activity is disrupted and prelimbic cortex low-gamma cross-frequency phase coupling tends to be decreased

• mutant mice fail to display the nucleus accumbens low-gamma cross-frequency phase coupling observed in wild-type mice during behaviorally immobile periods

• mutants exhibit neuronal entrainment deficits in nucleus accumbens

• lithium treatment ameliorates the nucleus accumbens phase-signaling dysfunction

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
bipolar disorder		DOID:3312		J:166742