nervous system
• nucleus accumbens medium spiny neurons have longer and more complex dendrites and exhibit reduced GluR1 expression than those of wild-type mice
• lithium treatment reverses the changes in dendritic morphology
|
• nucleus accumbens medium spiny neurons have longer and more complex dendrites and exhibit reduced GluR1 expression than those of wild-type mice
|
• phase coupling between nucleus accumbens low-gamma oscillatory activity and delta activity is disrupted and prelimbic cortex low-gamma cross-frequency phase coupling tends to be decreased
• mutant mice fail to display the nucleus accumbens low-gamma cross-frequency phase coupling observed in wild-type mice during behaviorally immobile periods
• mutants exhibit neuronal entrainment deficits in nucleus accumbens
• lithium treatment ameliorates the nucleus accumbens phase-signaling dysfunction
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
bipolar disorder | DOID:3312 | J:166742 |