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Phenotypes Associated with This Genotype
Genotype
MGI:4867863
cn15
Allelic
Composition		 Cdkn2atm1Rdp/Cdkn2atm1Rdp
E4f1tm1Pisc/E4f1tm1.1Llca
Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic
Background		 involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation (6 available); any Cdkn2a mutation (66 available)
E4f1tm1.1Llca mutation (2 available); any E4f1 mutation (38 available)
E4f1tm1Pisc mutation (1 available); any E4f1 mutation (38 available)
Polr2atm1(cre/ERT2)Bbd mutation (3 available); any Polr2a mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
hyperkeratosis ( J:167157 )
• development of hyperkeratosis following 4-hydroxytamoxifen treatment is reduced and delayed compared to mutant mice wild-type for Cdkn2a
epidermal hyperplasia ( J:167157 )
• development of hyperplasia following 4-hydroxytamoxifen treatment is reduced and delayed compared to mutant mice wild-type for Cdkn2a
abnormal keratinocyte physiology ( J:167157 )
• partial restoration in long term outgrowth of 4-hydroxytamoxifen exposed keratinocytes in culture compared to mutant mice wild-type for Cdkn2a

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory