Phenotypes Associated with This Genotype

Genotype
MGI:4868583

• Allelic Composition: Lmna^tm8Lgf/Lmna^tm8Lgf
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:167229 )

N • mice exhibit normal survival

cardiovascular system

abnormal heart left ventricle morphology ( J:167229 )

• at 12 months, mice exhibit slightly reduced left ventricular posterior wall thickness compared to in wild-type mice

decreased heart ventricle muscle contractility ( J:167229 )

• slightly at 12 months

cellular

abnormal cell nucleus morphology ( J:167229 )

• misshapen with blebs in fibroblasts and rarely in liver cells

adipose tissue

adipose tissue phenotype ( J:167229 )

N • mice exhibit normal body fat

growth/size/body

growth/size/body region phenotype ( J:167229 )

N • mice exhibit normal body weight curves

skeleton

skeleton phenotype ( J:167229 )

N • mice exhibit normal bone density

muscle

decreased heart ventricle muscle contractility ( J:167229 )

• slightly at 12 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	progeria	DOID:3911	OMIM:176670	J:167229