Phenotypes Associated with This Genotype

Genotype
MGI:4882107

• Allelic Composition: Sost^{tm1(KOMP)Vlcg}/Sost^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac
• Cell Lines: 10069B-C10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Higher bone mass in Rr20^tm1.1Vlcg/Rr20^tm1.1Vlcg and Sost^{tm1(KOMP)Vlcg}/Sost^{tm1(KOMP)Vlcg} mice

skeleton

skeleton phenotype ( J:188586 )

N • mice exhibit normal osteoclast activity

increased compact bone area ( J:188586 )

abnormal osteoblast morphology ( J:188586 )

• 3-fold increase in bone formation at the distal femur

• increased bone formation at the endocortical surface of the femur midshaft

abnormal trabecular bone morphology ( J:188586 )

• lower trabecular separation, increased osteoblast surface and reduced structure model index at 6 months

increased trabecular bone volume ( J:188586 )

• at 6 months

increased bone trabecula number ( J:188586 )

• at 6 months

increased trabecular bone connectivity density ( J:188586 )

• at 6 months

increased bone mass ( J:188586 )

• 3-fold

abnormal bone ossification ( J:188586 )

• 2-fold increase in bone formation at the distal femur

abnormal bone mineralization ( J:188586 )

• increased mineral apposition rate

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
SOST-related sclerosing bone dysplasia		DOID:0080036	OMIM:239100	J:188586