Phenotypes Associated with This Genotype

Genotype
MGI:4887901

• Allelic Composition: Tg(Plp)66Kan/0
• Genetic Background: B6NCrl.Cg-Tg(Plp)66Kan

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

ataxia ( J:156106 )

• at 15-18 months of age, mutants develop ataxia

growth/size/body

weight loss ( J:156106 )

• at 15-18 months of age, mutants begin to lose weight

nervous system

abnormal myelin sheath morphology ( J:156106 )

• slightly thinner myelin sheath

axon degeneration ( J:156106 )

• older mice exhibit axonal degeneration preferentially affecting smaller diameter fibers

demyelination ( J:156106 )

• mice show demyelination starting from 15-18 months of age

skeleton

kyphosis ( J:156106 )

• at 15-18 months of age, mutants develop kyphosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Pelizaeus-Merzbacher disease		DOID:3210	OMIM:312080	J:156106