Phenotypes Associated with This Genotype

Genotype
MGI:4888959

• Allelic Composition: Gria1^tm1Rsp/Gria1^tm1Rsp
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal emotion/affect behavior ( J:167264 )

• in the elevated plus-maze, mutants make more open and center entries and have more center time but less closed time, than wild-type mice

• lithium treatment partially rescues the elevated maze test phenotype, with mutants making fewer open entries compared to untreated mutants

• in the light/dark emergence test, mutants make more shelter exits and show more frequent scanning of the shelter than wild-type, although they do not spend more time out of the shelter than wild-type mice, indicating an increase in risk assessment

• in repeated exposure to elevated plus-maze, mutants make more open entries than wild-type, regardless of trial, and exhibit more open time; mutants make more closed arm entries on trial 2 but not trial 1

• all these behaviors are indicative of manic-like phenotype

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizoaffective disorder		DOID:5418		J:167264