Phenotypes Associated with This Genotype

Genotype
MGI:4889103

• Allelic Composition: Edar^dl-J/Edar^dl-J
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal circumvallate papillae morphology ( J:168036 )

• the embryonic CVP is dysplastic, appearing as a downward fissure rather than a raised dome

abnormal minor salivary gland morphology ( J:168036 )

• histological indications of developing minor salivary glands in E15.5 embryos are absent

• exogenous Fgf8 and Shh do not fully rescue lingual gland development in E13.5 tongue explants after 4 days in culture

absent anterior lingual gland ( J:168036 )

• in adult mutant mice

absent palatine gland ( J:168036 )

• in adult mutant mice

endocrine/exocrine glands

abnormal minor salivary gland morphology ( J:168036 )

• histological indications of developing minor salivary glands in E15.5 embryos are absent

• exogenous Fgf8 and Shh do not fully rescue lingual gland development in E13.5 tongue explants after 4 days in culture

absent anterior lingual gland ( J:168036 )

• in adult mutant mice

absent palatine gland ( J:168036 )

• in adult mutant mice

absent Meibomian glands ( J:50575 )

absent sweat gland ( J:50575 )

• there are no sweat glands on the footpads

integument

absent Meibomian glands ( J:50575 )

absent sweat gland ( J:50575 )

• there are no sweat glands on the footpads

abnormal coat appearance ( J:50575 )

• mutant mice have only one hair type that appears intermediate between guard and awl forms

absent hair follicles ( J:50575 )

• hair is not found on the tail

craniofacial

abnormal enamel knot morphology ( J:148176 )

• due to failure of cell condensation, the molars of developing mice have "ropes" of enamel cells extending across the tooth primordium rather than a central signaling center or enamel knot

abnormal circumvallate papillae morphology ( J:168036 )

• the embryonic CVP is dysplastic, appearing as a downward fissure rather than a raised dome

growth/size/body

abnormal enamel knot morphology ( J:148176 )

• due to failure of cell condensation, the molars of developing mice have "ropes" of enamel cells extending across the tooth primordium rather than a central signaling center or enamel knot

abnormal circumvallate papillae morphology ( J:168036 )

• the embryonic CVP is dysplastic, appearing as a downward fissure rather than a raised dome

vision/eye

absent Meibomian glands ( J:50575 )

skeleton

abnormal enamel knot morphology ( J:148176 )

• due to failure of cell condensation, the molars of developing mice have "ropes" of enamel cells extending across the tooth primordium rather than a central signaling center or enamel knot

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypohidrotic ectodermal dysplasia		DOID:14793		J:50575