Phenotypes Associated with This Genotype

Genotype
MGI:4889211

cx39

• Allelic Composition: Cmah^tm1Avrk/Cmah^tm1Avrk; Dmd^mdx/Dmd^mdx
• Genetic Background: involves: 129X1/SvJ * C57BL/10ScSn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:164594 )

♀ • 50% of mice dying by 11 months of age

♀ • mice exhibit decreased life span compared with Dmd^mdx homozygotes

muscle

cardiac muscle necrosis ( J:164594 )

♀ • by 3 months, mice exhibit necrotic foci in the heart unlike wild-type mice

skeletal muscle fibrosis ( J:164594 )

♀ • in the quadriceps at 6 weeks of age

♀ • fibrosis in the diaphragm is increased compared to in Dmd^mdx homozygotes

dystrophic muscle ( J:164594 )

♀ • more severe than in Dmd^mdx homozygotes

muscle weakness ( J:164594 )

♀ • at 8 months, mice exhibit impaired diaphragm and cardiac peak force compared with Dmd^mdx homozygotes

behavior/neurological

impaired coordination ( J:164594 )

♀ • at 8 months on a rotarod to a greater extent than in Dmd^mdx homozygotes

abnormal gait ( J:164594 )

♀ • at 8 months to a greater extent than in Dmd^mdx homozygotes

immune system

increased macrophage cell number ( J:164594 )

♀ • in muscles compared to in Dmd^mdx homozygotes

increased monocyte cell number ( J:164594 )

♀ • in muscles compared to in Dmd^mdx homozygotes

hematopoietic system

increased macrophage cell number ( J:164594 )

♀ • in muscles compared to in Dmd^mdx homozygotes

increased monocyte cell number ( J:164594 )

♀ • in muscles compared to in Dmd^mdx homozygotes

cardiovascular system

cardiac muscle necrosis ( J:164594 )

♀ • by 3 months, mice exhibit necrotic foci in the heart unlike wild-type mice