Phenotypes Associated with This Genotype

Genotype
MGI:4936849

• Allelic Composition: Itm2b^tm2.1Ldad/Itm2b⁺
• Genetic Background: B6.129-Itm2b^tm2.1Ldad

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:167154 )

abnormal object recognition memory ( J:167154 )

• at 5 to 6 months and 7 to 8 months, mice spend equal time exploring novel and old objects unlike wild-type mice

• at 11 months, mice exhibit profound memory impairment compared with wild-type mice

impaired spatial working memory ( J:167154 )

• at 5 to 6 months, 7 to 8 months, and 11 months, mice exhibit impaired spatial working memory in a radial-arm water maze compared with wild-type mice

nervous system

nervous system phenotype ( J:167154 )

N • mice do not exhibit neuron loss or taupathy

reduced long-term potentiation ( J:167154 )

• at 11 to 13 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cerebral amyloid angiopathy		DOID:9246		J:167154