Phenotypes Associated with This Genotype

Genotype
MGI:4936856

• Allelic Composition: Tg(KRT5-rtTA)#Glk/0; Tg(tetO-S100a7a)#Yus/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal chemokine secretion ( J:168000 )

• TPA-treated mice exhibit a 1.6-fold increase in RANTES (CCL5) production, 3-fold increase in MIP2 (CXCL2) production, and 3.7-fold increase in GM-CSF production compared with similarly treated single transgenic mice

increased interleukin-1 alpha secretion ( J:168000 )

• 3-fold in TPA-treated mice

increased tumor necrosis factor secretion ( J:168000 )

• 2-fold in TPA-treated mice

integument

abnormal skin morphology ( J:168000 )

• mice exhibit increased infiltration of CD3+ and CD4+ T cells in nonlesion skin unlike single transgenic mice

psoriasis ( J:168000 )

• mice treated with TPA or subjected to tape stripping develop psoriasis-like lesions to a greater extent than in similarly treated single transgenic mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
psoriasis		DOID:8893	OMIM:PS177900	J:168000