Phenotypes for Dmd Terc MGI:4936867 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Dmd^mdx/Y Terc^tm1Rdp/Terc⁺
Genetic Background	involves: 129/Sv * C57BL/6J * C57BL/10ScSn * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmd^mdx mutation (31 available); any Dmd mutation (156 available)
Terc^tm1Rdp mutation (4 available); any Terc mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

centrally nucleated skeletal muscle fibers ( J:167294 )

abnormal diaphragm morphology ( J:167294 )

• diaphragms exhibit increased diameter compared with control mice

abnormal muscle physiology ( J:167294 )

• muscle stem cell proliferation in undamaged muscles is higher than in control mice

homeostasis/metabolism

increased circulating creatine kinase level ( J:167294 )

• with increasing age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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