Phenotypes Associated with This Genotype

Genotype
MGI:4936868

• Allelic Composition: Adh7^tm1Gdu/Adh7^tm1Gdu
• Genetic Background: B6.129(Cg)-Adh7^tm1Gdu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:167234 )

N • mutants exhibit normal spontaneous rearing, motility and locomotion

enhanced behavioral response to xenobiotic ( J:167234 )

• administration of D-amphetamine significantly increases the motility and locomotion of 12-17 month old male mutants compared to wild-type mice

• administration of apomorphine results in a higher response in horizontal movement in 12-17 month old mutants than in wild-type mice

abnormal locomotor behavior ( J:167234 )

• administration of D-amphetamine significantly increases the motility and locomotion of 12-17 month old male mutants compared to wild-type mice

• administration of apomorphine results in a higher response in horizontal movement in 12-17 month old mutants than in wild-type mice

growth/size/body

decreased body weight ( J:167234 )

• males exhibit a lower weight than controls at 12-17 months of age

nervous system

abnormal substantia nigra morphology ( J:167234 )

• levels of dopamine and dopamine dihydroxyphenylacetic acid (DOPAC), a monoamine metabolite, are increased in the substantia nigra

abnormal olfactory bulb morphology ( J:167234 )

• significantly increased levels of the monoamine metabolite, DOPAC are observed in the olfactory bulb, however levels of dopamine are normal

taste/olfaction

impaired olfaction ( J:167234 )

• 18-20 month old mutants exhibit impaired olfaction, with mice showing longer times to find an odor target than wild-type mice

homeostasis/metabolism

increased dopamine level ( J:167234 )

• levels of dopamine and dopamine dihydroxyphenylacetic acid (DOPAC), a monoamine metabolite, are increased in the substantia nigra

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease		DOID:14330	OMIM:PS168600	J:167234