Phenotypes Associated with This Genotype

Genotype
MGI:4939025

• Allelic Composition: Tg(Igh-Maf)524Staka/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased plasma cell number ( J:168074 )

• in the spleen and bone marrow

abnormal spleen morphology ( J:168074 )

• infiltration of plasma-like cells partially destroys normal tissue architecture

enlarged spleen ( J:168074 )

• 2- to 5-fold

increased immunoglobulin level ( J:168074 )

• after 60 weeks, mice exhibit hyperglobulinemia compared with wild-type mice

increased IgG level ( J:168074 )

• in aged mice

increased IgM level ( J:168074 )

• in 50% of mice between 20 and 50 weeks

• in aged mice

neoplasm

increased lymphoma incidence ( J:168074 )

• 28% of mice develop lymphoma (mean age of diagnosis is 80 weeks)

• in 35% of mice at 120 weeks of age

• lymphoma cells exhibit autonomous proliferation when transplanted into nude mice

renal/urinary system

renal cast ( J:168074 )

• after 60 weeks, mice exhibit renal tubular casts and tubular obstructions compared with wild-type mice

hematopoietic system

increased plasma cell number ( J:168074 )

• in the spleen and bone marrow

abnormal spleen morphology ( J:168074 )

• infiltration of plasma-like cells partially destroys normal tissue architecture

enlarged spleen ( J:168074 )

• 2- to 5-fold

increased immunoglobulin level ( J:168074 )

• after 60 weeks, mice exhibit hyperglobulinemia compared with wild-type mice

increased IgG level ( J:168074 )

• in aged mice

increased IgM level ( J:168074 )

• in 50% of mice between 20 and 50 weeks

• in aged mice

growth/size/body

enlarged spleen ( J:168074 )

• 2- to 5-fold

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple myeloma		DOID:9538	OMIM:254500	J:168074