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Phenotypes Associated with This Genotype
Genotype
MGI:4940096
Allelic
Composition		 Brca2tm1Brn/Brca2tm1Cam
Krastm4Tyj/Kras+
Trp53tm3Tyj/Trp53+
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2tm1Brn mutation (5 available); any Brca2 mutation (132 available)
Brca2tm1Cam mutation (0 available); any Brca2 mutation (132 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53tm3Tyj mutation (3 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased pancreatic acinar cell carcinoma incidence ( J:166678 )
• about 18% of assessable tumor cases develop an acinar-cell carcinoma component of pancreatic tumors
increased pancreatic ductal adenocarcinoma incidence ( J:166678 )
• high penetrance (29 of 30 mutants) of pancreatic ductal adenocarcinomas

mortality/aging
premature death ( J:166678 )
• average survival time is 84 days, with a range of 48-110 days

endocrine/exocrine glands
increased pancreatic acinar cell carcinoma incidence ( J:166678 )
• about 18% of assessable tumor cases develop an acinar-cell carcinoma component of pancreatic tumors
increased pancreatic ductal adenocarcinoma incidence ( J:166678 )
• high penetrance (29 of 30 mutants) of pancreatic ductal adenocarcinomas

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
pancreatic carcinoma DOID:4905 OMIM:260350
 J:166678

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory