Phenotypes Associated with This Genotype

Genotype
MGI:4940318

cx23

• Allelic Composition: Dmd^mdx/Dmd^mdx; Dusp1^tm1Brv/Dusp1^tm1Brv
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/10ScSn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

myositis ( J:162340 )

♀ • mice exhibit enhanced inflammatory response in skeletal muscles compared with Dmd^mdx homozygotes

decreased skeletal muscle fiber size ( J:162340 )

♀ • compared with Dmd^mdx homozygotes

decreased skeletal muscle fiber diameter ( J:162340 )

♀ • compared with Dmd^mdx homozygotes

skeletal muscle fiber degeneration ( J:162340 )

♀ • increased compared to in Dmd^mdx homozygotes

decreased skeletal muscle weight ( J:162340 )

♀ • in the tibialis anterior and gastrocnemius compared with Dmd^mdx homozygotes

dystrophic muscle ( J:162340 )

♀ • mice exhibit an exacerbated dystrophic phenotype compared with Dmd^mdx homozygotes

immune system

myositis ( J:162340 )

♀ • mice exhibit enhanced inflammatory response in skeletal muscles compared with Dmd^mdx homozygotes

behavior/neurological

decreased grip strength ( J:162340 )

♀ • compared with Dmd^mdx homozygotes

growth/size/body

decreased body size ( J:162340 )

♀ • at 8 weeks compared with Dmd^mdx homozygotes

decreased body weight ( J:162340 )

♀ • at 8 weeks compared with Dmd^mdx homozygotes