Phenotypes Associated with This Genotype

Genotype
MGI:4940545

• Allelic Composition: Dag1^tm4.1Kcam/Dag1^tm4.1Kcam
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

centrally nucleated skeletal muscle fibers ( J:169291 )

dystrophic muscle ( J:169291 )

nervous system

abnormal neuromuscular synapse morphology ( J:169291 )

• neuromuscular-junctions are round and immature compared to in wild-type mice

• neuromuscular-junction maturation is impaired compared to in wild-type mice

behavior/neurological

limb grasping ( J:169291 )

• in 13 of 19 mice

decreased grip strength ( J:169291 )

cardiovascular system

cardiovascular system phenotype ( J:169291 )

N • mice exhibit normal cardiac function

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal recessive limb-girdle muscular dystrophy type 2P		DOID:0110293	OMIM:613818	J:169291