Phenotypes Associated with This Genotype

Genotype
MGI:4941028

• Allelic Composition: Tg(Mt1-GH1)#Jjk/0
• Genetic Background: C57BL/6J-Tg(Mt1-GH1)#Jjk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased percent body fat/body weight ( J:132437 )

• mutants exhibit lower percent body fat compared to controls

behavior/neurological

abnormal food intake ( J:132437 )

• mutants exhibit higher total food consumption compared to controls, although this difference is not statistically significant when normalized for differences in body size

growth/size/body

increased heart weight ( J:157146 )

• mean heart weight is increased in mutants as is the heart weight to body weight ratio

cardiac hypertrophy ( J:157146 )

increased body weight ( J:132437 , J:157146 )

• increase in body weight at 160% that of controls (J:132437)

increased kidney weight ( J:132437 )

• kidney weight is somewhat increased even after normalizing for differences in body size

increased liver weight ( J:132437 )

• liver weight is increased even after normalizing for differences in body size

homeostasis/metabolism

decreased circulating leptin level ( J:132437 )

• lowered serum leptin levels at 5 months of age

decreased circulating adiponectin level ( J:132437 )

• decrease in serum adiponectin levels at 5 months of age

liver/biliary system

increased liver weight ( J:132437 )

• liver weight is increased even after normalizing for differences in body size

nervous system

increased brain weight ( J:132437 )

• brain weight is increased even after normalizing for differences in body size

renal/urinary system

increased kidney weight ( J:132437 )

• kidney weight is somewhat increased even after normalizing for differences in body size

cardiovascular system

abnormal artery morphology ( J:157146 )

• distal mesenteric arteries have an increased wall thickness and cross-sectional area across the pressure range of 3-180 mm Hg

• however, lumen diameter of distal mesenteric arteries in not different from controls

increased heart weight ( J:157146 )

• mean heart weight is increased in mutants as is the heart weight to body weight ratio

cardiac hypertrophy ( J:157146 )

increased systemic arterial systolic blood pressure ( J:157146 )

• mean systolic blood pressure is higher compared to controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acromegaly		DOID:2449		J:157146