Phenotypes Associated with This Genotype

Genotype
MGI:4941487

• Allelic Composition: Slitrk6^tm1.1Jaru/Slitrk6^tm1.1Jaru
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:169557 )

N • mice exhibit normal swimming, contact righting, rotarod performance, and anxiety-related behavior

abnormal behavior ( J:169557 )

• in a hole-board test, mice exhibit increased total duration of head dipping and decreased latency to head dip compared with wild-type mice

• mice exhibit a decrement in immobility time when suspended by the tail compared with wild-type mice

decreased startle reflex ( J:169557 )

abnormal vertical vestibuloocular reflex ( J:169557 )

• mice exhibit decreased vertical vestibulo-ocular reflex compared with wild-type mice

• however, mice exhibit normal horizontal vestibulo-ocular reflex and horizontal optokinetic response

decreased locomotor activity ( J:169557 )

• mice exhibit a slight decrease in activity during the dark phase compared with wild-type mice

• in an open field test, mice exhibit less activity and spend more time in the center of the area compared with wild-type mice

hyperactivity ( J:169557 )

• during the light phase

hearing/vestibular/ear

abnormal vertical vestibuloocular reflex ( J:169557 )

• mice exhibit decreased vertical vestibulo-ocular reflex compared with wild-type mice

• however, mice exhibit normal horizontal vestibulo-ocular reflex and horizontal optokinetic response

increased or absent threshold for auditory brainstem response ( J:169557 )

growth/size/body

decreased body weight ( J:169557 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
sensorineural hearing loss		DOID:10003		J:169557