Phenotypes Associated with This Genotype

Genotype
MGI:4941606

• Allelic Composition: Tg(FCGR2A)11Mkz/0; Tg(PF4)#Zcy/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:72220 )

• following treatment with KKO and heparin, 2 of 4 mice die unlike similarly treated single transgenic mice

hematopoietic system

thrombocytopenia ( J:72220 )

• following treatment with KKO and heparin

homeostasis/metabolism

increased susceptibility to induced thrombosis ( J:72220 )

• following treatment with KKO and heparin, mice exhibit fibrin thrombi in the arterioles and capillaries in the heart, liver, lungs, and kidney unlike similarly treated single transgenic mice

decreased body temperature ( J:72220 )

• following treatment with KKO and heparin

behavior/neurological

hunched posture ( J:72220 )

• following treatment with KKO and heparin

decreased locomotor activity ( J:72220 )

• following treatment with KKO and heparin

respiratory system

respiratory distress ( J:72220 )

• following treatment with KKO and heparin

immune system

increased acute inflammation ( J:72220 )

• following treatment with KKO and heparin, mice exhibit severe thrombopenia, decreased activity, rapid shallow breathing, hunched posture, and tactile hypothermia with increased lethality and fibrin thrombi in the arterioles and capillaries in the heart, liver, lungs, and kidney compared with similarly treated single transgenic mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acquired thrombocytopenia		DOID:11126		J:72220