Phenotypes Associated with This Genotype

Genotype
MGI:4941907

• Allelic Composition: Pink1^tm1Hbu/Pink1^tm1Hbu
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased interleukin-1 beta secretion ( J:169471 )

• in the striatum of LPS-treated mice

increased interleukin-10 secretion ( J:169471 )

• in the striatum of LPS-treated mice

increased interleukin-12 secretion ( J:169471 )

• in the striatum of LPS-treated mice

cellular

abnormal mitochondrial physiology ( J:169471 )

• brain mitochondria exhibit reduced threshold for calcium-induced permeability transition pore opening compared with wild-type mitochondria

homeostasis/metabolism

decreased dopamine level ( J:169471 )

• at 6 months, mice exhibit decreased dopamine in the striatum due to increased dopamine turnover compared with wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 6		DOID:0060369	OMIM:605909	J:169471