Phenotypes Associated with This Genotype

Genotype
MGI:4942179

• Allelic Composition: Tg(Ins2-Hnf1a)#Cbw/0
• Genetic Background: involves: C57BL/6 * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased pancreatic alpha cell number ( J:134757 )

• at 10 weeks

abnormal pancreatic beta cell morphology ( J:134757 )

• beta cells exhibit swollen mitochondria and disorganized and dilated endoplasmic reticulum unlike in wild-type cells

decreased pancreatic beta cell number ( J:134757 )

• at 3 and 10 weeks

disorganized pancreatic islets ( J:134757 )

• at 3 and 10 weeks

increased glucagon secretion ( J:134757 )

• 2.2-fold in the pancreas at 10 weeks in male mice

decreased insulin secretion ( J:134757 )

• in the pancreas at 3, 6, and 10 weeks

• in beta cells of male mice stimulated with glucose and arginine

homeostasis/metabolism

increased glucagon secretion ( J:134757 )

• 2.2-fold in the pancreas at 10 weeks in male mice

decreased insulin secretion ( J:134757 )

• in the pancreas at 3, 6, and 10 weeks

• in beta cells of male mice stimulated with glucose and arginine

increased circulating glucose level ( J:134757 )

• in fasting and nonfasting mice and in response to a glucose tolerance test

decreased circulating insulin level ( J:134757 )

• in response to glucose challenge after an overnight fast

impaired glucose tolerance ( J:134757 )

• male mice become overtly diabetic and female mice exhibit glucose intolerance compared with wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young type 3		DOID:0111102	OMIM:600496	J:134757