Phenotypes Associated with This Genotype

Genotype
MGI:4942363

• Allelic Composition: Tg(Cma1-cre)ARoer/0; Tg(Kit*D814V)1Roer/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

colitis ( J:169611 )

• all mice develop intestinal inflammation similar to that in mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn

hematopoietic system

increased mast cell number ( J:169611 )

• develop mastocytosis similar to that in mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn

• accumulation of mast cells in the skin and in some cases also in the spleen

• disease symptoms occur later and disease progression is slower compared to mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn

neoplasm

increased skin tumor incidence ( J:169611 )

• mast cell tumors are seen in some mice

immune system

colitis ( J:169611 )

• all mice develop intestinal inflammation similar to that in mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn

increased mast cell number ( J:169611 )

• develop mastocytosis similar to that in mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn

• accumulation of mast cells in the skin and in some cases also in the spleen

• disease symptoms occur later and disease progression is slower compared to mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn

integument

increased skin tumor incidence ( J:169611 )

• mast cell tumors are seen in some mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
mastocytosis		DOID:350	OMIM:154800	J:169611