Phenotypes Associated with This Genotype

Genotype
MGI:4942396

• Allelic Composition: Tlr2^tm1Aki/Tlr2^tm1Aki
• Genetic Background: NOD.129P2-Tlr2^tm1Aki

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:124334 )

• significantly reduced susceptibility to type 1 diabetes

• 38% are diabetic at 45 weeks as compared to 74% of controls

endocrine/exocrine glands

insulitis ( J:124334 )

• reduced insulitis relative to controls

immune system

insulitis ( J:124334 )

• reduced insulitis relative to controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	type 1 diabetes mellitus	DOID:9744	OMIM:222100	J:124334