Phenotypes Associated with This Genotype

Genotype
MGI:4943326

• Allelic Composition: Tg(Lck-Tnfsf15,-EGFP)#Targ/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestinal goblet cell morphology ( J:169462 )

• the number of goblet cells per villi in the duodenum, jejunum, and ileum is increased compared with wild-type mice

• however, aged mice exhibit normal numbers of goblet cells

increased Paneth cell number ( J:169462 )

• the number of Paneth cells per villi in the duodenum, jejunum, and ileum is increased compared with wild-type mice

• however, the number of Paneth cells in the duodenum in aged mice is normal

abnormal ileum morphology ( J:169462 )

• ileum exhibit increased lamina propria mononuclear cell numbers compared to in wild-type mice

blunted small intestinal villi ( J:169462 )

• villi are blunted at 2 and 10 months

intestinal fibrosis ( J:169462 )

• in the colonic mucosa and submucosa by 10 months

small intestinal inflammation ( J:169462 )

• mild, detected by myeloperoxidase (MPO) activity

• however, MPO activity in the colon is normal

immune system

small intestinal inflammation ( J:169462 )

• mild, detected by myeloperoxidase (MPO) activity

• however, MPO activity in the colon is normal

increased CD4-positive, alpha-beta memory T cell number ( J:169462 )

• at 2 months, CD4+ CD44+ T cells are increased 2-fold in the spleen compared to in wild-type mice

• at 10 months, CD4+ CD44+ T cells are increased in the spleen and mesenteric lymph nodes compared to in wild-type mice

increased CD8-positive, alpha-beta memory T cell number ( J:169462 )

• at 10 months, CD8+ CD44+ T cells are increased in the spleen and mesenteric lymph nodes compared to in wild-type mice

increased interferon-gamma secretion ( J:169462 )

• at 10 months, mice exhibit a 3-fold increase in CD4+ IFN-gamma+ cells in mesenteric lymph nodes compared with wild-type mice

• IFN-gamma production in the mesenteric lymph node and small intestine lamina propria mononuclear cells compared to in wild-type mice

increased interleukin-17 secretion ( J:169462 )

• at 10 months, mice exhibit a 2-fold increase in CD4+ IL17+ cells in mesenteric lymph nodes compared with wild-type mice

skeleton

hemarthrosis ( J:169462 )

abnormal joint morphology ( J:169462 )

• 2 of 51 mice develop arthropathy unlike wild-type mice

• 3 of 4 mice develop monoarticular arthropathy and the remaining mouse exhibited polyarticular arthropathy

joint swelling ( J:169462 )

• mice develop swollen joints that cause difficulty moving compared with wild-type mice

integument

skin lesions ( J:169462 )

• 2 of 51 mice develop erythematous ulcerated skin lesions compared with 1 of 155 wild-type mice

cardiovascular system

hemarthrosis ( J:169462 )

endocrine/exocrine glands

increased Paneth cell number ( J:169462 )

• the number of Paneth cells per villi in the duodenum, jejunum, and ileum is increased compared with wild-type mice

• however, the number of Paneth cells in the duodenum in aged mice is normal

hematopoietic system

increased CD4-positive, alpha-beta memory T cell number ( J:169462 )

• at 2 months, CD4+ CD44+ T cells are increased 2-fold in the spleen compared to in wild-type mice

• at 10 months, CD4+ CD44+ T cells are increased in the spleen and mesenteric lymph nodes compared to in wild-type mice

increased CD8-positive, alpha-beta memory T cell number ( J:169462 )

• at 10 months, CD8+ CD44+ T cells are increased in the spleen and mesenteric lymph nodes compared to in wild-type mice

cellular

abnormal intestinal goblet cell morphology ( J:169462 )

• the number of goblet cells per villi in the duodenum, jejunum, and ileum is increased compared with wild-type mice

• however, aged mice exhibit normal numbers of goblet cells

homeostasis/metabolism

joint swelling ( J:169462 )

• mice develop swollen joints that cause difficulty moving compared with wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
inflammatory bowel disease 16		DOID:0110896	OMIM:612259	J:169462