Phenotypes Associated with This Genotype

Genotype
MGI:4944273

• Allelic Composition: Errfi1^tm1Jwj/Errfi1^tm1Jwj; Pgr^tm2(cre)Lyd/Pgr⁺; Pten^tm1Hwu/Pten^tm1Hwu
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:162027 )

• survival time of double mutants is shorter than either single mutant, with mice dying by 16 weeks of age

reproductive system

increased endometrial carcinoma incidence ( J:162027 )

♀ • development of endometrial cancer is accelerated compared to either single mutant

abnormal endometrium morphology ( J:162027 )

♀ • decrease in the number of apoptotic cells in the endothelium epithelium compared to single Pten mutants

♀ • proliferation is increased in the endothelium epithelium

endometrium hyperplasia ( J:162027 )

♀ • mutants exhibit endometrial hyperplasia at 2 weeks of age and develop endometrial adenocarcinoma at 4 weeks of age

♀ • however, myometrial hyperplasia is not observed in the uteri of mutants

increased uterus weight ( J:162027 )

♀ • increase in uterine weight at 2 weeks of age, with weight at 4 weeks greater than in single Pten mutants

neoplasm

increased metastatic potential ( J:162027 )

• mutants exhibit distant metastases into the ovary, diaphragmatic skeletal muscle, lymph node, colon and pancreas

increased endometrial carcinoma incidence ( J:162027 )

♀ • development of endometrial cancer is accelerated compared to either single mutant

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
endometrial cancer		DOID:1380	OMIM:608089	J:162027