Phenotypes Associated with This Genotype

Genotype
MGI:4946518

cn6

• Allelic Composition: Stk11^tm1Keis/Stk11^tm1Keis; Tg(Pomc1-cre)1Gsb/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:170130 )

N • mice exhibit normal energy expenditure, leptin concentration, and fasted plasma insulin levels

N • male mice exhibit normal glucose metabolism

abnormal gluconeogenesis ( J:170130 )

• hepatic glucose production induced by pyruvate or insulin is increased compared to in wild-type mice

impaired glucose tolerance ( J:170130 )

• in female mice, but not male mice

abnormal glycogen homeostasis ( J:170130 )

• female mice exhibit reduced whole-body glycogen synthesis compared with wild-type mice

insulin resistance ( J:170130 )

• after an insulin tolerance test, female mice exhibit reduced glucose clearance compared with wild-type mice

behavior/neurological

decreased fluid intake ( J:170130 )

• in mice treated with MT2

• however, unstimulated food intake is normal

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:170130 )

N • male and female mice exhibit normal pancreatic islet architecture, beta cell mass, and function

nervous system

nervous system phenotype ( J:170130 )

N • mice exhibit normal POMC neuron numbers compared with wild-type mice

N • POMC neurons exhibit normal glucose sensing