Phenotypes for Kras Map2k7 MGI:4948962 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Kras^tm4Tyj/Kras⁺ Map2k7^tm1.1Twad/Map2k7^tm1.2Twad
Genetic Background	B6.Cg-Kras^tm4Tyj Map2k7^tm1.1Twad/Map2k7^tm1.2Twad

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (12 available); any Kras mutation (90 available)
Map2k7^tm1.1Twad mutation (0 available); any Map2k7 mutation (20 available)
Map2k7^tm1.2Twad mutation (0 available); any Map2k7 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:170904 )

neoplasm

increased lung tumor incidence ( J:170904 )

• following adenovirus cre infection, mice exhibit increased lung tumor burden compared with control mice

increased lung adenocarcinoma incidence ( J:170904 )

cellular

abnormal DNA repair ( J:170904 )

• following adenovirus cre infection, mice exhibit impaired DNA damage response compared with control mice

homeostasis/metabolism

abnormal DNA repair ( J:170904 )

• following adenovirus cre infection, mice exhibit impaired DNA damage response compared with control mice

respiratory system

increased lung tumor incidence ( J:170904 )

• following adenovirus cre infection, mice exhibit increased lung tumor burden compared with control mice

increased lung adenocarcinoma incidence ( J:170904 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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